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KMID : 0356719980140040719
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Journal of the Korean Society of Coloproctology
1998 Volume.14 No. 4 p.719 ~ p.724
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The Prognostic Significance of Tumor Microvessel Density in Colorectal Carcinoma
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Lee Jeong-Kyun
Han Won-Cheol
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Abstract
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Purpose:This study was carried out to evaluate the relationship with other clinicopath ologic factors and prognostic significance of tumor microvessel density in colorectal car cinoma.
Material and Methods: 71cases of primary colorectal carcinoma (Modified Astler-Coller stage B and C) were analysed retrospectively who underwent curative resection at Wonkwang university hospital from September, 1991 to September, 1993. Male was 39cases. Age under 60 years was 31cases. 5 year survival rates were 80% (50 cases) in stage B and 52.4% (21 cases) in stage C. Tumor microvessels were stained by immuno histochemical method using anti-CD31 on paraffine embedded tissues, and were counted within 10x objective field (about 0.74 mm2) in the area of the most intense neovascu larization.
Results: Mean microvessel Density (MVD) was 56.3 18.0 (range 19∼128). MVD was 55.2 in 11 cases of nonrecurrent group and 73.5 in 10 cases of recurrent group in stage C (p=0.012). There was no significant association between MVD and other parameters such as age, sex, tumor location and size, CEA, lymph node metastasis, and survival. The 5 year survival rates of 33 cases of MVD≤56 and 38 cases of MVD＞56 were 84.9 and 60.5% respectively(p＜0.05). 5 year survival rates of
MVD≤56 groups adjusted for age, sex, tumor location, differentiation, and recurrence were higher than those of ＞56 groups. 5 year survival rates of MVD ≤56 and ＞56 groups in stage C were 100% (5 cases) and 37.5% (16 cases) (p 0.05).
Conclusion:Tumor microvessl density may have somewhat prognostic significance in colorectal carcinoma.
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KEYWORD
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Colorectal carcinoma, Microvessel density
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